Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study

Introduction: Nigella sativa, also known as black seed, cumin, and/or Habbatul Barakah, is a medicinal herbal plant. Thymoquinone (TQ), one of sativa's active ingredients, has been shown to be anticarcinogenic, anti-inflammatory, analgesic, and antimicrobial. Hydroxyapatite (HA) an inorganic mineral with the apatite lattice structure (A10(BO4)6C2). The aim current study incorporate thymoquinone blackcumin hydroxyapatite crystals form new nanoformulation find out its cytotoxicity antimicrobial properties against dental pathogens. Materials method: Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Candida albicans were species used. efficacy nanoparticles was evaluated using agar well diffusion method at different concentrations ranging from 25 micron litres 100 litres. UV double beam spectrophotometers in wavelength range 250-750nm used characterise synthesised nanoparticles. Results: zone inhibition mutans found highest L concentration. As nano formulation solution increased, mean grew. Conclusion: showed that there potential property aureus antifungal activity